Q1.    Answer ALL parts of this question

(a)      Explain the meaning of the following NMR terms:

(i)       NOESY

(ii)      HSQC

In your answer critically discuss the experiments, describe both the typical results and the structural  information  that  may  be  obtained  by  using  these  techniques.  Include  a  fully annotated diagram of the 2D spectral profiles (topology) expected for (i) and (ii).

[22 marks]

(b)     In NMR spectroscopy what does PFG stand for? What hardware is

required to run PFG experiments and suggest two advantages of using this application over non-PFG experiments?

[5 marks]

(c)      From your knowledge of the scientific literature critically evaluate the TOCSY NMR experiment. In your answer, provide possible applications for this technique.

[6 marks]

[Total 33 Marks]

Q2.    Answer ALL parts of this question

(a)

(i)       Draw and label a schematic diagram for the main components comprising a mass spectrometer.

[5 Marks]

(ii)     What process does each region of a mass spectrometer perform in

order to collect mass spectrometry data?

[8 Marks]

(b)     Identify the three possible reactions that can occur when a neutral

molecule, M, undergoes Electron Ejection Ionisation, labelling all

species present.

[6 Marks]

(c)      Consider the mass spectrum below, along with the molecular formula Cm HnXY, where X and Y represent halogen atoms.

(i)       Identify X and Y from a calculation of relative isotope abundance.

[12 Marks]

(ii)      Identify the monoisotopic Molecular Ion Peak, by mass-to-charge

ratio, in the mass spectrum given above.

[2 Marks]

[Total 33 marks]

Q3.    Answer BOTH parts of this question